Diabetes mellitus (DM) is considered a major public health problem because\nof its high prevalence and progressive increase of incidence. DM chronic\ncomplications are major causes of morbidity and mortality, among which diabetic\nneuropathy (DN) stands out, affecting 30% - 50% of DM patients. An\nappropriate medical approach, involving anamnesis and thorough clinical\nexamination, is extremely important for the early diagnosis of DN and, therefore,\nto the prevention of its complications, including the amputation of\nlimbs. Despite of the importance of DN prevention and treatment, in order to\nprovide improved quality of life and longevity to DM patients, current therapeutic\noptions are very limited with respect to both symptom control and as\neffective disease therapies. Intensive glucose control is extremely important in\norder to prevent and avoid the progression of DN, as demonstrated in two\nlarge multicenter studies involving patients with type 1 DM, the DCCT (Diabetes\nControl and Complications Trial) and the EDIC (Epidemiology of Diabetes\nInterventions and Complications).
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